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Advances in Topical Antifungal Therapy - download pdf or read online

By R. J. Hay (auth.), R. J. Hay MD, MRCP, MRCPath. (eds.)

ISBN-10: 3540173021

ISBN-13: 9783540173021

ISBN-10: 3642717179

ISBN-13: 9783642717178

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Extra resources for Advances in Topical Antifungal Therapy

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Tessendorf, Germany: Did you have to use it for a longer time on these areas, or only for a short time such as 20 min? Petri, Germany: Only for a relatively short time, and from there on we did not see any side effects. Panconesi, Italy: I want to ask Dr. Petri if this so-called antiinflammatory action in his experience is only an antihistamic affecting a vasodilatory action. Petri, Germany: I dont't think so, we have discussed this already and perhaps it has to be said that the effect of bifonazole on keratinase is proteolytic or keratinolytic.

2) was 5 days in the bifonazole group, 7 days in the oxiconazole group and as long as 10 days in the naftifine group. 0003) . 'vluIHlII ANOVA I 10..... ll~" II 'Jill,. ')l1I 101 rklllllm",or tlrH) 8J IpI Illlu4IfIIllltllnl rIr 11 VII III " I '0',,1111' ft' f)(M,,),! ''' U""I 111111 Ilnrl N(Jlhhrif' (I,-OO()OJ) Fig. 2. Clinical improvement of candidosis after start of treatment assessment of therapeutic results (Fig. 3) 2 weeks after the termination of treatment. The outcome was rated as "very good" in 90% of patients treated with bifonazole, 73% of patients treated with Ircolm nl J very good Bifonazole - 27 9()

3). 0 Bifonazole ug/ml Fig. 3. Bifonazo1e effect on keratinase secretion 24 enzyme activity was reduced by 50%, and at 20 ng/ml by nearly 100% compared to the bifonazole-free medium. The main reasons for the clinical antimycotic efficacy of bifonazole are: - direct antimycotic effect - reduction of fungal virulence with subinhibitory concentrations in vivo - influence on the secretion of keratinolytic enzyme activity in dermatophytes In addition to the direct antimycotic activity of the agent and to its capacity to reduce the in vivo virulence offungi even at subinhibitory concentrations, this effect on the secretion of keratinolytic enzymes may be a third important reason for the clinical efficacy of bifonazole.

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Advances in Topical Antifungal Therapy by R. J. Hay (auth.), R. J. Hay MD, MRCP, MRCPath. (eds.)


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